Rapid prototyping and modular design
To identify the best multi-functional therapies
DotBio’s platform is based on the concept of rapid prototyping and modular design, which has revolutionized industries such as the car, micro-chips, and the building industries.
Antibody modules with specific functions (e.g., tumor targeting, immune activation, cytokine blockade) are prefabricated and optimized for potency and stability. These modules can be used as building blocks to assemble antibody molecules with different architectures and modes of action.
This straightforward process eliminates the requirement for extensive protein engineering efforts, leading to drastically reduced development time. Since the generation of multi-functional antibodies is simplified, DotBio can generate a large number of prototypes molecules with different specificities and configurations in parallel. The prototypes are tested rapidly in miniaturized high throughput assays to identify the optimal therapeutic candidate.
Bank of DotBody modules against major disease targets
DotBio has a constantly expanding bank of DotBody modules targeting a wide variety of disease drivers. These include cancer-specific targets (e.g., HER2 and EGFR), immune checkpoints (e.g., PD1 and CTLA4), signaling molecules in the tumor microenvironment (e.g., VEGF and TGFβ) as well as targets specific to different immune cells population in the tumor environment (e.g., MDSCs, TAMs and TAFs).